I recently made the switch. Running intel ultra 5 and nvidia rtx 5060. Bazzite and Pop!_OS were advertised as working, out of the box. I couldn’t get either to work, following the wiki setup guides. I tried Ubuntu, couldn’t get that working, either.
I switched to Nobara, and learned that I was messing up gamemoderun in Steam. So I have no idea if Nobara fixed my issues, or if I was messing something up the whole time, or maybe a little of both. It was fun, though! Absolutely glad to be done with windows.
I made the switch recently. I tried Pop and Bazzite, but neither worked out of the box for me. I switched to Nobara, and then found out I was using Gamemode incorrectly, so I don’t know if that was causing my problems, or if Nobara does something differently.
Since then, Protondb has had all the tinkering tips I’ve needed, which is generally just copy and paste.