If you wanna be thorough:
Right-click the game in lutris > Configure > Runner options > Output debugging info > Enabled. -> Output of Lutris > Game > View last game’s log or run in in terminal and sent the output of terminal.
Skim through the output for any indictations of crashes, errors, dumps. Try deciphering it yourself first than punch it in your browser.
What I usually try before going into debugging is changing the version of wine I am using. Its quite useful installing Protonplus via flathub or the AUR (though there are a lot more community packages for fedora/bazzit too)
Install Proton-GE via Protonplus and set it as your default for Lutris -> Restart Lutris > Try starting the game again.
Lil word of warning
I also started noticing games not launching via Lutris recently and since I essentially only use it to launch Steam games and the occasional Heroic Games Launcher game, I stopped using it altogether, only later I found out that the lead dev apparently started using a lot more AI vibe coding when pushing updates. Now I dont know to what extend since the developer decided to scrub all signatures made by Claude but thats just my little conspiracy theory.
Its a bit embarrassing but I’m moderately dyslexic, using autocorrect especially for words like the “tho” words (though, thought, thorough, etc.) So I got it mixed up.