Not really. I haven’t played in a long time, but I’d say to keep storage like freight next to your production rooms. And if you’re trying to be efficient, don’t get cutesy and put elevators in random spots; stack them in columns. It makes settlers able to move around much more quickly.

Keep people with decent stats, armor, and weapons stationed at your vault door. Any attacks will be quickly dealt with and you won’t have to worry about anything. The last time I played, I had someone with max stats and power armor, along with a max-stat Preston, with a fatman and a rocket launcher.